Keunggulan L-PRF Dibandingkan P-PRF, PRFM, A-PRF, & I-PRF sebagai Cangkok pada Operasi Miringoplasti: Studi Penyembuhan Luka pada Perforasi Membran Timpani

Authors

  • Antonius Christanto Universitas Sebelas Maret
  • Risya Cilmiaty Universitas Sebelas Maret
  • Made Setiamika Universitas Sebelas Maret
  • Ratih Dewi Yudhani Universitas Sebelas Maret
  • Paramasari Dirgahayu Universitas Sebelas Maret

DOI:

https://doi.org/10.54259/sehatrakyat.v5i1.6020

Keywords:

A-PRF, I-PRF, L-PRF, Myringoplasty, Tympanic Membrane

Abstract

This study aims to analyze the advantages of Leukocyte-Platelet Rich Fibrin (L-PRF) application in myringoplasty surgery compared to other platelet concentrates such as Platelet-Rich Fibrin Membrane (PFRM), Advanced Platelet-Rich Fibrin (A-PRF), and Injectable Platelet-Rich Fibrin (I-PRF). The research method used is a qualitative literature review, collecting and analyzing data from recent scientific journals and clinical studies related to the use of L-PRF in tympanic membrane repair. The study finds that L-PRF, with its dense fibrin network and high content of leukocytes and growth factors, enhances tissue regeneration, angiogenesis, and epithelialization, which are critical for successful graft integration and faster healing after myringoplasty. Compared to other platelet concentrates, L-PRF offers better mechanical strength and a more sustained release of growth factors. Additionally, L-PRF reduces postoperative complications and improves hearing outcomes. Being an autologous biomaterial, it also reduces the risk of immune rejection. The findings suggest that L-PRF is a promising graft material in otologic surgery, though further clinical trials are needed to optimize its application protocols.

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References

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Published

2026-02-15

How to Cite

Antonius Christanto, Risya Cilmiaty, Made Setiamika, Ratih Dewi Yudhani, & Paramasari Dirgahayu. (2026). Keunggulan L-PRF Dibandingkan P-PRF, PRFM, A-PRF, & I-PRF sebagai Cangkok pada Operasi Miringoplasti: Studi Penyembuhan Luka pada Perforasi Membran Timpani. Sehat Rakyat: Jurnal Kesehatan Masyarakat, 5(1), 74–83. https://doi.org/10.54259/sehatrakyat.v5i1.6020

Issue

Vol. 5 No. 1 (2026): Februari 2026

Section

Articles

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Copyright (c) 2026 Antonius Christanto, Risya Cilmiaty, Made Setiamika, Ratih Dewi Yudhani, Paramasari Dirgahayu

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