Systematic Journal Review: The Effect of Age and Obesity on Chronic Rhinitis and Allergic Rhinitis
DOI:
https://doi.org/10.54259/sehatrakyat.v5i1.6501Keywords:
Age, Allergic Rhinitis, Chronic Rhinitis, Obesity, Systematic ReviewAbstract
Chronic rhinitis and allergic rhinitis are common inflammatory upper airway diseases with substantial clinical impact. Age and obesity are considered potential determinants influencing disease occurrence and presentation. This study aimed to systematically evaluate the effects of age and obesity on chronic rhinitis and allergic rhinitis. A Systematic Journal Review was conducted following PRISMA guidelines. Literature searches were performed in PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar from 2020 to 2025. Eligible studies were qualitatively analyzed using narrative synthesis. Ten primary studies were included in the final analysis. Older age was consistently associated with a higher prevalence of non-allergic chronic rhinitis, while allergic rhinitis predominated in children and young adults. Obesity was significantly associated with chronic rhinitis in adults. However, findings regarding obesity and allergic rhinitis in children and adolescents were inconsistent. The interaction between age and obesity influenced clinical phenotype and disease severity. Age and obesity significantly affect rhinitis occurrence with distinct patterns across age groups.
Downloads
References
Blüher, M. (2020). Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083874.pdf
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., & Fokkens, W. J. (2020). Allergic rhinitis. Nature Reviews Disease Primers. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093406.pdf
Calderon Martinez, E., Ghattas Hasbun, P. E., Salolin Vargas, V. P., García-González, O. Y., Fermin Madera, M. D., Rueda Capistrán, D. E., Campos Carmona, T., Sanchez Cruz, C., & Teran Hooper, C. (2024). A comprehensive guide to conduct a systematic review and meta-analysis in medical research. Medicine, 103(21), e41868. https://doi.org/10.1097/MD.0000000000041868
Ciprandi, G., Gelardi, M., & Incorvaia, C. (2022). Chronic rhinitis in the elderly. Clinical and Molecular Allergy. https://clinicalmolecularallergy.biomedcentral.com/counter/pdf/10.1186/s12948-022-00173-9.pdf
Han, Y.-Y., Forno, E., Gogna, M., & Celedón, J. C. (2016). Obesity and rhinitis in a nationwide study of children and adults in the United States. Journal of Allergy and Clinical Immunology, 137(5), 1460–1465. https://doi.org/10.1016/j.jaci.2015.12.1307
Harugop, A. S., Mudhol, R. S., & Hajare, S. T. (2020). Obesity and allergic rhinitis in children. Journal of Clinical and Diagnostic Research. https://www.jcdr.net/articles/PDF/13746/42919_CE[Ra1]_F(KM)_PF1(AG_KM)_PN(SL).pdf
Harugop, A. S., Walia, A., Havaldar, R. R., & Mudhol, R. S. (2020). Correlation between allergic rhinitis and body mass index: An observational study. Indian Journal of Otolaryngology and Head & Neck Surgery, 74(Suppl 2), S1033–S1036. https://doi.org/10.1007/s12070-020-02095-2
Kais, A., Hunt, C., Makary, C. A., & Ramadan, H. H. (2024). Impact of allergic rhinitis on quality of life in patients with chronic rhinosinusitis. American Journal of Otolaryngology, 45(4), 104325. https://doi.org/10.1016/j.amjoto.2024.104325
Khanna, D., Khanna, S., Khanna, P., Kahar, P., & Patel, B. M. (2022). Obesity: A chronic low-grade inflammation and its markers. Cureus, 14(2), e22711. https://doi.org/10.7759/cureus.22711
Kim, D. H., Kim, J. H., & Kim, S. W. (2021). Age-related changes in nasal mucosa. Allergy, Asthma & Immunology Research. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069875.pdf
Listyaningrum, H. F., Sekarhandini, P., & Vidya, P. (2023). Hubungan obesitas dengan kejadian rinitis alergi pada siswa SMP di Surakarta berdasarkan Kuesioner ISAAC. Medical Science and Hospital Management Journal, 1(2), 35–43.
Listyaningrum, R., Riyadina, W., & Kristanti, I. (2023). Obesity and allergic rhinitis among Indonesian adolescents. Kesmas: Jurnal Kesehatan Masyarakat Nasional. https://journal.fkm.ui.ac.id/kesmas/article/download/5156/1644
Morąg, B., Kozubek, P., & Gomułka, K. (2023). Obesity and selected allergic and immunological diseases etiopathogenesis, course and management. Nutrients, 15(17), 3813. https://doi.org/10.3390/nu15173813
Nam, J.-S., Ha, J.-G., Roh, Y. H., Fahad, W. A., Noh, H.-E., Yoon, J.-H., Kim, C.-H., & Cho, H.-J. (2021). Association between obesity and chronic rhinosinusitis with nasal polyps: A national population-based study. BMJ Open, 11(5), e047230. https://doi.org/10.1136/bmjopen-2020-047230
Organization, W. H. (2023). Obesity and noncommunicable diseases. Bulletin of the World Health Organization. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452047.pdf
Pan, J., Xu, G., Zhai, Z., Sun, J., Wang, Q., Huang, X., Guo, Y., Lu, Q., Mo, J., Nong, Y., Huang, J., & Lu, W. (2024). Geriatric nutritional risk index as a predictor for fragility fracture risk in elderly with type 2 diabetes mellitus: A 9-year ambispective longitudinal cohort study. Clinical Nutrition, 43(5), 1125–1135. https://doi.org/10.1016/j.clnu.2024.03.032
Pan, Y., Zhang, R., & Liu, W. (2024). Age, obesity, and chronic rhinitis. Frontiers in Immunology. https://www.frontiersin.org/articles/10.3389/fimmu.2024.1298743/pdf
Papadopoulou, A.-M., Chrysikos, D., Samolis, A., Tsakotos, G., & Troupis, T. (2021). Anatomical variations of the nasal cavities and paranasal sinuses: A systematic review. Cureus, 13(2), e12727. https://doi.org/10.7759/cureus.12727
Poklepović Peričić, T., & Tanveer, S. (2019). Why systematic reviews matter. In Elsevier Connect. https://www.elsevier.com/en-gb/connect/why-systematic-reviews-matter
Shaheen, N., Shaheen, A., Ramadan, A., Hefnawy, M. T., Ramadan, A., Ibrahim, I. A., Hassanein, M. E., Ashour, M. E., & Flouty, O. (2023). Appraising systematic reviews: A comprehensive guide to ensuring validity and reliability. Frontiers in Research Metrics and Analytics, 8, 1268045. https://doi.org/10.3389/frma.2023.1268045
Tai, J., Jeong, Y., Lee, K., Han, M., Kim, T. H., & Park, J. (2024). Analysis of age-related prevalence and risk factors of chronic rhinosinusitis with asthma. Ear, Nose & Throat Journal, 103(1), 55–61. https://doi.org/10.1177/01455613221121022
Van Woudenbergh, E., van Rooijen, D. M., Veldman-Wolf, J. J., Nicolaie, M. A., Huynen, M. A., van der Klis, F. R. M., de Jonge, M. I., & den Hartog, G. (2024). Effect of age and season on respiratory mucosal immune marker profiles. Journal of Allergy and Clinical Immunology, 153(6), 1681–1691. https://doi.org/10.1016/j.jaci.2023.12.009
Voltan, C., Concer, F., Pecoraro, L., Pietrobelli, A., Piacentini, G., & Zaffanello, M. (2024). Exploring the complex interplay of obesity, allergic diseases, and sleep-disordered breathing in children. Children, 11(5), 595. https://doi.org/10.3390/children11050595
Yu, H., Wang, L., & Zhang, Q. (2023). Obesity, air pollution, and allergic rhinitis. Environmental Research. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154241.pdf
Yu, M., Pan, M., Liang, Y., Li, X., Li, J., & Luo, L. (2023). A nomogram for screening sarcopenia in Chinese type 2 diabetes mellitus patients. Experimental Gerontology, 172. https://doi.org/10.1016/j.exger.2022.112069
Yum, H. Y., Ha, E. K., Shin, Y. H., & Han, M. Y. (2021). Prevalence, comorbidities, diagnosis, and treatment of nonallergic rhinitis: Real-world comparison with allergic rhinitis. Clinical and Experimental Pediatrics, 64(8), 373–383. https://doi.org/10.3345/cep.2020.00822
Zhou, J., Luo, F., Han, Y., Lou, H., Tang, X., & Zhang, L. (2020). Obesity/overweight and risk of allergic rhinitis: A meta-analysis of observational studies. Allergy. https://doi.org/10.1111/all.14143
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Nabila Azzahra Permata Putri
This work is licensed under a Creative Commons Attribution 4.0 International License.
Hak cipta pada setiap artikel adalah milik penulis.
Penulis mengakui bahwa SEHATRAKYAT (Jurnal Kesehatan Masyarakat) sebagai publisher yang mempublikasikan pertama kali dengan lisensi Creative Commons Attribution 4.0 International License.
Penulis dapat memasukan tulisan secara terpisah, mengatur distribusi non-ekskulif dari naskah yang telah terbit di jurnal ini kedalam versi yang lain, seperti: dikirim ke respository institusi penulis, publikasi kedalam buku, dan lain-lain. Dengan mengakui bahwa naskah telah terbit pertama kali pada SEHATRAKYAT (Jurnal Kesehatan Masyarakat).
